Victor M. Lasehinde, MSc.

Research Toxicologist & Scientific Operations Leader | MBA Candidate
St. Louis, US.

About

Highly accomplished Research Toxicologist and MBA Candidate with 3+ years of hands-on experience in pharmacology, toxicology, and molecular biology, specializing in hazard identification, in-vitro safety screening, and GLP-compliant research. Proven leader in optimizing laboratory operations, driving scientific innovation through advanced assay development, and translating complex data into actionable insights for cross-functional teams and high-impact publications. Adept at strategic planning, cost reduction, and fostering collaborative environments, with a strong commitment to safer chemistry and non-animal testing methods.

Work

Washington University
|

Voluntary Scientific Collaborator

St. Louis, MO, US

Summary

Leading advanced assay development and data analysis initiatives to support hazard identification and mechanistic interpretation of biological responses in a research environment.

Highlights

Spearheaded the optimization and development of the laboratory's chromatin immunoprecipitation (ChIP) assay during prior tenure, establishing robust, validated protocols for crosslinking, sonication, antibody selection, and qPCR validation that remain actively in use.

Provided expert technical guidance and toxicology-relevant data interpretation, informing biological risk characterization and strategic decision-making for ongoing research projects.

Developed and disseminated comprehensive procedural documentation and virtual demonstrations, facilitating consistent execution and training for new personnel in complex ChIP workflows.

Delivered critical data analysis support for hazard identification and mechanistic interpretation of biological responses, utilizing validated in vitro assays to advance research objectives.

Washington University
|

Molecular Biology Research Technician and De Facto Lab Manager

St. Louis, MO, US

Summary

Managed end-to-end laboratory operations and spearheaded critical research initiatives in molecular biology, contributing to significant scientific publications and operational efficiencies.

Highlights

Executed comprehensive in vitro cytotoxicity and dose-response experiments, supporting robust hazard identification and contributing to the preclinical evaluation of novel compounds.

Pioneered biomarker discovery and validation through epigenetic analyses and molecular diagnostic assay development (ChIP, qRT-PCR, dual luciferase), directly contributing to 4 co-authored publications in high-impact journals (Mol Cell, JBC).

Characterized stress-induced protein and RNA expression changes using Western blotting, Northern blotting, and SDS-PAGE, enabling quantitative analysis of pathway activation and ensuring sample quality for downstream applications.

Engineered custom plasmids for gene expression studies via molecular cloning (SNAPGene, Addgene) and validated subcellular localization and protein interactions using immunofluorescence microscopy and flow cytometry.

Processed and analyzed complex experimental data, quantifying gel images with Image Quant and performing statistical analysis in GraphPad Prism, resulting in publication-ready figures and presentations for scientific dissemination.

Contributed to 4 high-impact publications (Molecular Cell, JBC) by executing multi-channel research campaigns and translating complex data into actionable scientific insights, mirroring market strategy development.

Managed end-to-end laboratory operations for NIH-funded projects, including inventory control, vendor negotiations, and scheduling, reducing annual operational costs by $65K (20%) through strategic vendor management and supply chain optimization.

Ensured audit-ready, GLP-compliant documentation, managed equipment/supply inventories, and oversaw sample logistics, maintaining regulatory adherence and operational efficiency.

Wright State Physicians
|

Intern

Fairborn, OH, US

Summary

Supported clinical trial operations and ensured GCP compliance for patient safety monitoring and data integrity.

Highlights

Supported human safety monitoring and clinical data integrity under ICH-GCP guidelines, conducting patient safety assessments for 100+ clinical samples in hidradenitis suppurativa and atopic dermatitis studies.

Managed the collection, processing, and chain-of-custody for over 100 clinical samples, ensuring strict adherence to ICH-GCP guidelines and contributing to a co-authored publication (Cureus).

Wright State University
|

Student/Research Assistant

Dayton, OH, US

Summary

Conducted cell-based toxicological screening and biomarker research, contributing to publications and developing robust analytical workflows.

Highlights

Performed cell-based toxicological screening and cytotoxicity testing using high-content imaging and quantitative image analysis (Image Quant, GraphPad Prism), assessing compound efficacy for antidiabetic drug candidates and contributing to a co-authored publication in Frontiers in Microbiology.

Supported dose-response modeling and comparative toxicity evaluation by developing sample preparation protocols for novel renal injury biomarkers (KIM-1), creating robust workflows for analytical characterization via Western blotting, ELISA, and SDS-PAGE.

Synthesized complex datasets using GraphPad Prism, Minitab, and JMP for statistical analysis, and leveraged Adobe Photoshop & Illustrator to create professional, publication-ready figures.

Authored and contributed to research grant applications, SOPs, and technical reports, ensuring comprehensive documentation of methodologies and findings for scientific dissemination.

Education

University of the Cumberlands
Louisville, KY, United States of America

MBA

Business Administration

Wright State University
Dayton, OH, United States of America

MSc.

Pharmacology and Toxicology

Obafemi Awolowo University
Ile Ife, Nigeria

BSc.

Biochemistry

Awards

UBORA Award for Excellence

Awarded By

Wright State University

Recognized for exceptional academic and research contributions at Wright State University.

Phi Kappa Phi Honor Society Member

Awarded By

Wright State University

Inducted into the nation's oldest and most selective collegiate honor society for all academic disciplines.

Publications

Multiprotein bridging factor 1 is required for robust activation of the integrated stress response on collided ribosomes.

Published by

Mol Cell.

Summary

Co-authored publication detailing the role of multiprotein bridging factor 1 in activating the integrated stress response on collided ribosomes, published in a high-impact journal.

eIF4F complex dynamics are important for the activation of the integrated stress response.

Published by

Mol Cell.

Summary

Co-authored publication investigating the dynamics of the eIF4F complex and its importance in activating the integrated stress response, featured in a high-impact journal.

Inability to rescue stalled ribosomes results in overactivation of the integrated stress response.

Published by

Journal of Biological Chemistry

Summary

Co-authored publication exploring the consequences of stalled ribosomes leading to overactivation of the integrated stress response, published in the Journal of Biological Chemistry.

Clinical Analysis and Applications of mRNA Vaccines in Infectious Diseases and Cancer Treatment.

Published by

Cureus

Summary

Co-authored publication providing a clinical analysis and discussing the applications of mRNA vaccines in infectious diseases and cancer treatment, published in Cureus.

Screening for potential novel probiotic Levilactobacillus brevis RAMULAB52 with antihyperglycemic property from fermented Carica papaya L.

Published by

Front Microbiol.

Summary

Co-authored publication on the screening of a novel probiotic with antihyperglycemic properties from fermented Carica papaya L., published in Frontiers in Microbiology.

Certificates

Lean Sigma, Green Belt

Issued By

Wright State University

Lean Sigma, Black Belt

Issued By

Wright State University

Skills

Laboratory Techniques

Hazard Identification, Dose-Response Assessment, Exposure Assessment, Risk Characterization, Safety Substantiation, GLP Documentation, In Vitro Toxicology (NAMs), Yeast Cell Culture, Bacterial Cell Culture, Bacterial Transformation, Yeast Transformation, Pipetting, Plasmid Design, Primer Design, RNA Extraction (kit and hot phenol: chloroform), DNA Extraction (kit and hot phenol: chloroform), Western Blotting, Northern Blotting, SDS-PAGE, Chromatin Immunoprecipitation, Immunofluorescence Microscopy, Ribosome Profiling, Confocal Microscopy, Quantitative PCR, RT-PCR, Dual Luciferase Assay, Cell Sorting (Flow Cytometry), Molecular Cloning, Experimental Design, Thin Layer Chromatography, Immunohistochemistry, FFPE, Nuclear Staining (DAPI and Hoechst Stain).

Data Analysis & Software

Microsoft Office (Excel, Word, PowerPoint, Outlook), Adobe Photoshop, Adobe Illustrator, GraphPad Prism, Image Lab, Image Quant, Minitab, JMP, SNAPGENE, Addgene, Tableau, Statistical Software, Scientific Visualization, Data Interpretation.

Research & Development

Biomarker Discovery, Assay Development, Process Optimization, Scientific Writing, Research Grant Applications, SOP Development, Technical Reports, Clinical Sample Management, ICH-GCP Guidelines, Regulatory Compliance, Scientific Communication, Translational Research, Project Management, Vendor Management, Supply Chain Optimization, Operational Management.